To investigate the relationship between urine specific gravity (USG) and the risk of arterial hypotension during general anaesthesia in healthy dogs that received a dexmedetomidine & methadone premedication.
Prospective clinical cohort study.
A total of 75 healthy client owned dogs undergoing general anaesthesia for elective tibial-plateau-levelling osteotomy.
After placing an intravenous catheter, dogs were premedicated with dexmedetomidine (5 μg kg-1) and methadone (0.3 mg kg-1) intravenously. After induction of general anaesthesia with alfaxalone given to effect, the bladder was expressed, and USG was measured. An arterial catheter was placed, and residual blood was used to measure packed cell volume (PCV) and total protein (TP). General anaesthesia was maintained with isoflurane vaporised in oxygen and a femoral and sciatic nerve block were performed. Arterial blood pressure < 60 mmHg was defined as hypotension and recorded by the anaesthetist. Treatment for hypotension was performed in a stepwise manner following a flow chart. Frequency of hypotension, treatment, and response to treatment were recorded. Logistic regression modelling was used to assess the association between USG, TP, and PCV and incidence of perioperative hypotension. p < 0.05.
Data from 14 dogs were excluded. Of the 61 dogs 16 (26 %) were hypotensive during general anaesthesia, 15 dogs needed treatment of which 12 were responsive to a decrease in inhalant vaporiser setting. The logistic regression model was not statistically significant (p = 0.8). There was no significant association between USG (p = 0.6), TP (p = 0.4), PCV (p = 0.8) and arterial hypotension during general anaesthesia.
Conclusion and clinical relevance
In, healthy dogs premedicated with dexmedetomidine and methadone and maintained under general anaesthesia with isoflurane and a femoral and sciatic nerve block, there was no relationship between the specific gravity of urine collected after premedication and intraoperative arterial hypotension.
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Accepted: January 7, 2023
Received in revised form: January 5, 2023
Received: March 29, 2022
Publication stageIn Press Journal Pre-Proof
© 2023 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.