Abstract
Objective
To evaluate effects of repeated alfaxalone or propofol administration on haematological
and serum biochemical variables in cats undergoing radiotherapy.
Study Design
Prospective, block-randomized, clinical trial.
Animals
A group of 39 client-owned cats
Methods
After butorphanol (0.2 mg kg-1) & midazolam (0.1 mg kg-1) sedation, cats were randomly assigned to receive either alfaxalone or propofol for
induction of anaesthesia and sevoflurane maintenance. Cats were anaesthetized daily
with the same induction agent for 10-12 days. Complete blood counts, reticulocytes,
Heinz body score, and serum biochemistry were performed before the first treatment
(T1), at T6, T10 and 3 weeks after the final treatment (T21). Cumulative induction
agent dose for each cat at each time point was evaluated for an effect on Heinz body
score. Data are shown as mean ± standard deviation. p < 0.05
Results
At baseline there were no significant differences in signalment or blood variables
between groups. A significant decrease in haematocrit 2.3% ± 0.77, (p = 0.02) between T1-T6 and T1-T10 [mean 4.1% (±0.78, p < 0.0001)] was detected, with a significant increase in haematocrit of 2.1% ± 0.80,
(p = 0.046) between T6-T21 and 4.0% ± 0.8, (p < 0.001) between T10-T21. Heinz body score significantly increased by 1.86 ± 0.616,
(p = 0.013) between T1-T10. In the propofol group reticulocytes increased significantly
between T1-T6 mean 23,090 μL-1 ± 7,670, (p = 0.02) and T1-T10 mean 27,440 μL-1 ± 7,990 (p = 0.007). Mean cumulative dose at T10 was 19.65 mg kg-1 ± 5.3 and 43.4 mg kg-1 ± 14.4 for alfaxalone and propofol respectively, with no significant effect on Heinz
body formation at any time point.
Conclusions and Clinical Relevance
Haematocrit decreased in both groups with recovery after 3 weeks. Repeated alfaxalone
and propofol administration was not associated with marked haematological or serum
biochemistry changes.
Keywords
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Article info
Publication history
Accepted:
November 21,
2022
Received in revised form:
October 30,
2022
Received:
January 11,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
