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Comparison of alfaxalone or propofol on haematological and serum biochemical variables in cats undergoing radiotherapy with sevoflurane maintenance

  • Maximilian Körner
    Correspondence
    Corresponding author.
    Affiliations
    Department for Small Animals, Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
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  • Carla Rohrer Bley
    Correspondence
    Corresponding author.
    Affiliations
    Department for Small Animals, Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
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  • Rima Bektas
    Affiliations
    Department of Diagnostics and Clinical Services, Section Anaesthesiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 258c, 8057 Zurich, Switzerland
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  • Barbara Riond
    Affiliations
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
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  • Friederike Wolf
    Affiliations
    Department for Small Animals, Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
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  • Valeria Meier
    Correspondence
    Corresponding author. Valeria Meier Division of Radiation Oncology, Vetsuisse Faculty, University of ZurichDivision of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland
    Affiliations
    Department for Small Animals, Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
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Published:November 25, 2022DOI:https://doi.org/10.1016/j.vaa.2022.11.010

      Abstract

      Objective

      To evaluate effects of repeated alfaxalone or propofol administration on haematological and serum biochemical variables in cats undergoing radiotherapy.

      Study Design

      Prospective, block-randomized, clinical trial.

      Animals

      A group of 39 client-owned cats

      Methods

      After butorphanol (0.2 mg kg-1) & midazolam (0.1 mg kg-1) sedation, cats were randomly assigned to receive either alfaxalone or propofol for induction of anaesthesia and sevoflurane maintenance. Cats were anaesthetized daily with the same induction agent for 10-12 days. Complete blood counts, reticulocytes, Heinz body score, and serum biochemistry were performed before the first treatment (T1), at T6, T10 and 3 weeks after the final treatment (T21). Cumulative induction agent dose for each cat at each time point was evaluated for an effect on Heinz body score. Data are shown as mean ± standard deviation. p < 0.05

      Results

      At baseline there were no significant differences in signalment or blood variables between groups. A significant decrease in haematocrit 2.3% ± 0.77, (p = 0.02) between T1-T6 and T1-T10 [mean 4.1% (±0.78, p < 0.0001)] was detected, with a significant increase in haematocrit of 2.1% ± 0.80, (p = 0.046) between T6-T21 and 4.0% ± 0.8, (p < 0.001) between T10-T21. Heinz body score significantly increased by 1.86 ± 0.616, (p = 0.013) between T1-T10. In the propofol group reticulocytes increased significantly between T1-T6 mean 23,090 μL-1 ± 7,670, (p = 0.02) and T1-T10 mean 27,440 μL-1 ± 7,990 (p = 0.007). Mean cumulative dose at T10 was 19.65 mg kg-1 ± 5.3 and 43.4 mg kg-1 ± 14.4 for alfaxalone and propofol respectively, with no significant effect on Heinz body formation at any time point.

      Conclusions and Clinical Relevance

      Haematocrit decreased in both groups with recovery after 3 weeks. Repeated alfaxalone and propofol administration was not associated with marked haematological or serum biochemistry changes.

      Keywords

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