Abstract
Objective
To assess the effect of two intravenous (IV) doses of lidocaine on the minimum anesthetic
concentration (MAC) of isoflurane in chickens.
Study design
Blinded, prospective, randomized, experimental crossover study.
Animals
A total of six adult female chickens weighing 1.90 ± 0.15 kg.
Methods
Chickens were anesthetized with isoflurane and mechanically ventilated. Isoflurane
MAC values were determined (T0) in duplicate using an electrical noxious stimulus
and the bracketing method. After MAC determination, a low dose (LD; 3 mg kg–1 followed by 3 mg kg–1 hour–1) or high dose (HD; 6 mg kg−1 followed by 6 mg kg−1 hour–1) of lidocaine was administered IV. MAC determination was repeated at 1.5 (T1.5) and
3 (T3) hours of lidocaine administration and blood was collected for analysis of plasma
lidocaine and monoethylglycinexylidide (MEGX) concentrations. Pulse rate, peripheral
hemoglobin oxygen saturation, noninvasive systolic arterial pressure and cloacal temperature
were recorded at T0, T1.5 and T3. Treatments were separated by 1 week. Data were analyzed
using mixed-effects model for repeated measures.
Results
MAC of isoflurane (mean ± standard deviation) at T0 was 1.47 ± 0.18%. MAC at T1.5
and T3 was 1.32 ± 0.27% and 1.26 ± 0.09% (treatment LD); and 1.28 ± 0.06% and 1.30
± 0.06% (treatment HD). There were no significant differences between treatments or
times. Maximum plasma lidocaine concentrations at T3 were 496 ± 98 and 1200 ± 286
ng mL–1 for treatments LD and HD, respectively, and were not significantly different from
T1.5. With treatment HD, plasma concentration of MEGX was significantly higher at
T3 than at T1.5. Physiological variables were not significantly different among times
with either treatment.
Conclusions and clinical relevance
Administration of lidocaine did not significantly change isoflurane MAC in chickens.
Within treatments, plasma lidocaine concentrations were not significantly different
at 1.5 and 3 hours.
Keywords
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Article Info
Publication History
Published online: November 09, 2022
Accepted:
November 1,
2022
Received:
August 1,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
