Abstract
Objective
To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols
for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables.
Study design
Randomized clinical study.
Animals
A total of 33 dogs with pyometra with two or more systemic inflammatory response syndrome
variables undergoing ovariohysterectomy.
Methods
Dogs were randomized into two groups: group DG, dexmedetomidine (3 μg kg–1 hour–1; 17 dogs) and group FG, fentanyl (5 μg kg–1 hour–1; 16 dogs) infused during isoflurane anesthesia and mechanical ventilation. Microcirculation
flow index (MFI), total vessel density and De Backer score were assessed using orthogonal
polarization spectral imaging at the sublingual site. Heart rate, invasive blood pressure,
temperature, arterial blood gas analysis and lactate concentration were obtained at
various time points. Variables were recorded at baseline (BL), immediately before
(T0), 30 (T30) and 60 (T60) minutes after infusion, and 60 minutes after surgery.
Data were analyzed using the Shapiro-Wilk test. To compare variables between groups,
the unpaired Student t test was used. Comparison between evaluation time points was performed with two-way
anova for repeated measures. Where statistical significance was detected, the Bonferroni
post hoc test was used.
Results
MFI was significantly higher in group FG at T30. Mean arterial pressure at T30 was
higher in group DG (89 ± 15 mmHg) than in group FG (72 ± 13 mmHg). Lactate concentrations
were not significantly different between groups at each time point. Both groups had
similar clinical outcomes (mortality, extubation time and occurrence of hypotension
and bradyarrhythmias).
Conclusions and clinical relevance
Dexmedetomidine (3 μg kg–1 hour–1) without a loading dose can be included in the maintenance of anesthesia in dogs
with pyometra and sepsis without compromising microcirculation and hemodynamic values
when compared with fentanyl (5 μg kg–1 hour–1).
Keywords
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Article info
Publication history
Published online: July 20, 2022
Accepted:
July 14,
2022
Received:
December 17,
2021
Identification
Copyright
© 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
