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Immobilization of a juvenile Komodo dragon using alfaxalone subcutaneously

      The neuroactive steroid alfaxalone (3-α-hydroxy-5-α-pregnane-11,20-dione) has been used for anaesthesia with no complications in a variety of reptiles (
      • Scheelings T.F.
      • Baker R.T.
      • Hammersley
      • et al.
      Preliminary investigation into the chemical restraint with alfaxalone of selected Australian squamate species.
      ;
      • Knotek Z.
      Alfaxalone as an induction agent for anaesthesia in terrapins and tortoises.
      ;
      • Perrin K.L.
      • Bertelsen M.F.
      Intravenous alfaxalone and propofol anesthesia in the bearded dragon (Pogona vitticeps).
      ). In snakes, alfaxalone (3.7 mg kg–1) administered subcutaneously (SC) was successful in sedating a giant python allowing a second dose to be administered intravenously (IV) (
      • Freitag F.A.
      • Barboza T.K.
      • Dutton C.
      • Buck R.K.
      Alfaxalone for anesthesia of a giant snake.
      ). Alfaxalone administered IV has also been used to induce general anaesthesia in a perentie monitor, which is the only published report of its use in a reptile belonging to the genus Varanus (
      • Hoffman E.M.
      • Garrett K.
      • Doneley R.J.
      Pneumocoelom causing cloacal prolapse in a perentie monitor (Varanus giganteus).
      ). To date, the use of alfaxalone as an anaesthetic agent has not been reported in the Komodo dragon.
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      References

        • Freitag F.A.
        • Barboza T.K.
        • Dutton C.
        • Buck R.K.
        Alfaxalone for anesthesia of a giant snake.
        Vet Anaesth Analg. 2022; 49: 147-148
        • Fry B.G.
        • Wroe S.
        • Teeuwisse W.
        • et al.
        A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscus.
        Proc Natl Acad Sci U S A. 2009; 106: 8969-8974
        • Hoffman E.M.
        • Garrett K.
        • Doneley R.J.
        Pneumocoelom causing cloacal prolapse in a perentie monitor (Varanus giganteus).
        Aust Vet Pract. 2017; 47: 117-120
        • Knotek Z.
        Alfaxalone as an induction agent for anaesthesia in terrapins and tortoises.
        Vet Rec. 2014; 175: 327
        • Mosley C.A.
        • Dyson D.
        • Smith D.A.
        The cardiovascular dose-response effects of isoflurane alone and combined with butorphanol in the green iguana (Iguana iguana).
        Vet Anaesth Analg. 2004; 31: 64-72
        • Perrin K.L.
        • Bertelsen M.F.
        Intravenous alfaxalone and propofol anesthesia in the bearded dragon (Pogona vitticeps).
        Herpetol Med Surg. 2017; 27: 123-126
        • Scheelings T.F.
        • Baker R.T.
        • Hammersley
        • et al.
        Preliminary investigation into the chemical restraint with alfaxalone of selected Australian squamate species.
        J Herpetol Med Surg. 2011; 21: 63-77