Advertisement

The effect of preanaesthetic oral trazodone hydrochloride on the induction dose of propofol: a preliminary retrospective study

      Abstract

      Objective

      To determine whether the administration of trazodone to dogs 2 hours prior to radiotherapy treatment reduced the dose of propofol required to induce anaesthesia.

      Study design

      Retrospective, crossover, case-matched study.

      Animals

      Records of 30 client-owned dogs.

      Methods

      Anaesthetic records from all dogs undergoing weekly radiotherapy treatment between January 2020 and December 2020 were retrospectively assessed. All dogs were premedicated with 10 μg kg–1 alfentanil and 12 μg kg–1 atropine intravenously (IV) and anaesthesia was induced with IV propofol. In part 1, the propofol induction dose was compared between anaesthetics when trazodone was administered prior to the anaesthetic (T) versus not (NT). For part 2, control dogs not administered trazodone during the treatment course were case-matched based on bodyweight and tumour location and type. The propofol induction dose was compared between the first (C1) and last (C2) anaesthetic to identify the effects of confounding factors. A Wilcoxon signed-rank test for repeated measurements was performed to identify any significant differences in the propofol induction dose between NT and T in the study dogs and between C1 and C2 in the control dogs.

      Results

      In part 1, 15 study dogs that were administered trazodone prior to at least one anaesthetic were identified. A significant difference in propofol induction dose between groups NT and T was identified [3.3 (2.1–7.4) and 2.0 (1.5–5.0) mg kg–1, respectively; p = 0.003]. In part 2, 15 dogs were case-matched to the study cohort. The dose of propofol administered did not differ between the first and last anaesthetic [2.5 (1.6–6.4) and 2.6 (1.9–8.9) mg kg–1, respectively; p = 0.638].

      Conclusions and clinical relevance

      Preanaesthetic trazodone administration reduced the induction dose of propofol compared to when it was not administered to dogs following premedication with IV atropine and alfentanil.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Veterinary Anaesthesia and Analgesia
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Cohen Y.
        • Feldinger E.
        • Ogorek D.
        • Weinbroum A.A.
        Increased propofol requirement during succeeding administrations for electroconvulsive therapy.
        J Clin Anesth. 2004; 16: 282-285
        • Gilbert-Gregory S.E.
        • Stull J.W.
        • Rice M.R.
        • Herron M.E.
        Effects of trazodone on behavioral signs of stress in hospitalized dogs.
        J Am Vet Med Assoc. 2016; 249: 1281-1291
        • Gruen M.E.
        • Sherman B.L.
        Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases.
        J Am Vet Med Assoc. 2008; 233: 1902-1907
        • Gruen M.E.
        • Roe S.C.
        • Griffith E.
        • et al.
        Use of trazodone to facilitate postsurgical confinement in dogs.
        J Am Vet Med Assoc. 2014; 245: 296-301
        • Hoffman E.A.
        • Aarnes T.K.
        • Ricco Pereira C.H.
        • et al.
        Effect of oral trazodone on the minimum alveolar concentration of isoflurane in dogs.
        Vet Anaesth Analg. 2018; 45: 754-759
        • Jaffer K.Y.
        • Chang T.
        • Vanle B.
        • et al.
        Trazodone for insomnia: a systematic review.
        Innov Clin Neurosci. 2017; 14: 24-34
        • Kang R.
        • Shin B.S.
        • Shin Y.H.
        • et al.
        Incidence of tolerance in children undergoing repeated administration of propofol for proton radiation therapy: a retrospective study.
        BMC Anesthesiol. 2018; 18: 125
        • Li R.Y.
        • Lin M.
        • Jiang H.Y.
        • et al.
        Impact of anxiety or depression symptoms on propofol requirements for sedation in females: A prospective cohort study.
        J Clin Pharmacol. 2020; 60: 1376-1384
        • Mills D.S.
        • Mueller H.W.
        • McPeake K.
        • Engel O.
        Development and psychometric validation of the lincoln canine anxiety scale.
        Front Vet Sci. 2020; 7: 1-10
        • Murphy L.
        • Barletta M.
        • Graham L.
        • et al.
        Effects of acepromazine and trazodone on anesthetic induction dose of propofol and cardiovascular variables in dogs undergoing general anesthesia for orthopedic surgery.
        J Am Vet Med Assoc. 2017; 250: 408-416
        • Niggemann J.R.
        • Tichy A.
        • Eberspächer-Schweda M.C.
        • Eberspächer-Schweda E.
        Preoperative calming effect of melatonin and its influence on propofol dose for anaesthesia induction in healthy dogs.
        Vet Anaesth Analg. 2019; 46: 560-567
        • Stevens B.
        • Frantz E.
        • Orlando J.
        • et al.
        Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety.
        J Am Vet Med Assoc. 2016; 249: 202-207