Abstract
Objective
To determine whether the administration of trazodone to dogs 2 hours prior to radiotherapy
treatment reduced the dose of propofol required to induce anaesthesia.
Study design
Retrospective, crossover, case-matched study.
Animals
Records of 30 client-owned dogs.
Methods
Anaesthetic records from all dogs undergoing weekly radiotherapy treatment between
January 2020 and December 2020 were retrospectively assessed. All dogs were premedicated
with 10 μg kg–1 alfentanil and 12 μg kg–1 atropine intravenously (IV) and anaesthesia was induced with IV propofol. In part
1, the propofol induction dose was compared between anaesthetics when trazodone was
administered prior to the anaesthetic (T) versus not (NT). For part 2, control dogs not administered trazodone during the treatment
course were case-matched based on bodyweight and tumour location and type. The propofol
induction dose was compared between the first (C1) and last (C2) anaesthetic to identify
the effects of confounding factors. A Wilcoxon signed-rank test for repeated measurements
was performed to identify any significant differences in the propofol induction dose
between NT and T in the study dogs and between C1 and C2 in the control dogs.
Results
In part 1, 15 study dogs that were administered trazodone prior to at least one anaesthetic
were identified. A significant difference in propofol induction dose between groups
NT and T was identified [3.3 (2.1–7.4) and 2.0 (1.5–5.0) mg kg–1, respectively; p = 0.003]. In part 2, 15 dogs were case-matched to the study cohort. The dose of propofol
administered did not differ between the first and last anaesthetic [2.5 (1.6–6.4)
and 2.6 (1.9–8.9) mg kg–1, respectively; p = 0.638].
Conclusions and clinical relevance
Preanaesthetic trazodone administration reduced the induction dose of propofol compared
to when it was not administered to dogs following premedication with IV atropine and
alfentanil.
Keywords
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Article info
Publication history
Published online: May 06, 2022
Accepted:
January 5,
2022
Received:
March 15,
2021
Identification
Copyright
© 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
