Abstract
Objective
To evaluate the cyclooxygenases (COX) inhibition, adverse effects and analgesic efficacy
of dipyrone or meloxicam in cats undergoing elective ovariohysterectomy.
Study design
Prospective, blinded, randomized, clinical study.
Animals
A total of 30 healthy young cats.
Methods
The cats were randomly assigned to three postoperative groups: D25 (dipyrone 25 mg
kg−1 every 24 hours), D12.5 (dipyrone 12.5 mg kg−1 every 12 hours) and M (meloxicam 0.1 mg kg−1 every 24 hours). In the first 24 hours, the drugs were administered intravenously
(IV), and then orally for 6 (dipyrone) or 3 days (meloxicam). Prostanoids thromboxane
B2 and prostaglandin E2 concentrations served as indicators of COX activity and, with physiological variables
and pain and sedation scores, were measured for 24 hours after first analgesic administration.
Rescue analgesia (tramadol, 2 mg kg−1 IV) was provided if Glasgow feline composite measure pain scale (CMPS-Feline) ≥5.
Laboratory tests included symmetric dimethylarginine and adverse effects were evaluated
regularly up to 7 and 10 days after surgery, respectively. Parametric and nonparametric
data were analyzed with two-way anova and Kruskal-Wallis tests, respectively (p < 0.05).
Results
In the first half hour after analgesic administration, COX-1 activity was close to
zero and remained significantly lower than before drug administration for 24 hours
in all groups. The inhibition of COX-2 activity was significant for 30 minutes in
all groups and up to 4 hours in group M. No alterations in laboratory tests or significant
adverse effects were observed. Pain scores and need for rescue analgesia did not differ
statistically among groups.
Conclusions
Dipyrone at both doses and meloxicam provided a nonselective inhibition of COX-1 and
-2 activities and effective analgesia without causing significant adverse effects
or laboratory tests alterations.
Clinical relevance
Dipyrone at both doses provides equally effective analgesia without causing adverse
effects in cats undergoing ovariohysterectomy.
Keywords
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Article info
Publication history
Published online: November 02, 2020
Accepted:
October 18,
2020
Received:
June 1,
2020
Identification
Copyright
© 2020 Published by Elsevier Ltd on behalf of Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia.
