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Measurement of peripheral muscle oxygen saturation in conscious healthy horses using a near-infrared spectroscopy device

Published:August 07, 2019DOI:https://doi.org/10.1016/j.vaa.2019.07.001

      Abstract

      Objective

      Maintaining adequate muscle tissue oxygenation is of paramount importance during equine general anesthesia. The objectives of this study were to assess the feasibility, reliability and repeatability of near-infrared spectroscopy (NIRS) muscle oximetry using the Inspectra m650 in conscious healthy adult horses.

      Study design

      Prospective, observational study.

      Animals

      A group of 30 healthy client-owned adult horses admitted to the equine hospital between July 2017 and July 2018.

      Methods

      The probe of an Inspectra m650 NIRS tissue oximeter was placed on the hairless surface of five muscle sites (omotransversarius, triceps long head, extensor carpi ulnaris, vastus lateralis and lateral digital extensor) on the left side of the body of each standing, unsedated horse. Each site had muscle oxygenation (StO2) recordings measured in triplicate and statistical modeling used to assess the reading reliability and repeatability within and between muscle sites.

      Results

      The readings acquired at the vastus lateralis and extensor carpi ulnaris muscle sites had highly repeatable values [mean (90% confidence interval): StO2, 95% (93.8%, 96.5%) and 93% (91.6%, 93.9%), respectively; intraclass correlation coefficients, 0.92 and 0.80, respectively]. These two sites also had high reliability (represented by the percentage of successful readings; 70% and 86%, respectively).

      Conclusions and clinical relevance

      The use of NIRS muscle oxygenation technology is a clinically feasible means to assess tissue oxygenation in horses. The vastus lateralis and extensor carpi ulnaris muscle sites provided the most reliable and repeatable readings when using the Inspectra m650 machine in horses.

      Keywords

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      References

        • Abdelmalak B.B.
        • Cata J.P.
        • Bonilla A.
        • et al.
        Intraoperative tissue oxygenation and postoperative outcomes after major non-cardiac surgery: an observational study.
        Br J Anaesth. 2013; 110: 241-249
        • Akaike H.
        A new look at the statistical model identification.
        IEEE Trans Automat Contr. 1974; 19: 716-723
        • Bartels S.A.
        • Bezemer R.
        • Milstein D.M.J.
        • et al.
        The microcirculatory response to compensated hypovolemia in a lower body negative pressure model.
        Microvasc Res. 2011; 82: 374-380
        • Beekley A.C.
        • Martin M.J.
        • Nelson T.
        • et al.
        Continuous noninvasive tissue oximetry in the early evaluation of the combat casualty: a prospective study.
        J Trauma. 2010; 69: S14-S25
        • Brady K.
        • Hogue C.W.
        Intraoperative hypotension and patient outcome: does ‘one size fit all?.
        Anesthesiology. 2013; 119: 495-497
        • Cortés D.O.
        • Puflea F.
        • de Backer D.
        • et al.
        Near infrared spectroscopy (NIRS) to assess the effects of local ischemic preconditioning in the muscle of healthy volunteers and critically ill patients.
        Microvasc Res. 2015; 102: 25-32
        • Cournoyer A.
        • Denault A.
        • Cossette S.
        • et al.
        Reproducibility, interchangeability of measures, time to measure stabilization, and reference values of two tissue oximeters in healthy volunteers.
        J Biomed Opt. 2016; 21: 97003
        • Crookes B.A.
        • Cohn S.M.
        • Burton E.A.
        • et al.
        Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock.
        Surgery. 2004; 135: 662-670
        • Crookes B.A.
        • Cohn S.M.
        • Bloch S.
        • et al.
        Can near-infrared spectroscopy identify the severity of shock in trauma patients?.
        J Trauma. 2005; 58: 806-813
        • Crossland R.F.
        • Mitchell A.
        • Macko A.R.
        • et al.
        Rapid assessment of shock in a nonhuman primate model of uncontrolled hemorrhage: association of traditional and nontraditional vital signs to mortality risk.
        J Trauma Acute Care Surg. 2016; 80: 610-616
        • Duret J.
        • Pottecher J.
        • Bouzat P.
        • et al.
        Skeletal muscle oxygenation in severe trauma patients during haemorrhagic shock resuscitation.
        Crit Care. 2015; 19: 141
        • Engbers S.
        • Boysen S.R.
        • Engbers J.
        • Chalhoub S.
        A comparison of tissue oxygen saturation measurements by 2 different near-infrared spectroscopy monitors in 21 healthy dogs.
        J Vet Emerg Crit Care. 2014; 24: 536-544
        • Friedrichs K.R.
        • Harr K.E.
        • Freeman K.P.
        • et al.
        ASVCP reference interval guidelines: determination of de novo reference intervals in veterinary species and other related topics.
        Vet Clin Pathol. 2012; 41: 441-453
        • Georger J.F.
        • Hamzaoui O.
        • Chaari A.
        • et al.
        Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients.
        Intensive Care Med. 2010; 36: 1882-1889
        • Gerovasili V.
        • Dimopoulos S.
        • Tzanis G.
        • et al.
        Utilizing the vascular occlusion technique with NIRS technology.
        Int J Ind Ergon. 2010; 40: 218-222
        • Hall K.E.
        • Powell L.L.
        • Beilman G.J.
        • et al.
        Measurement of tissue oxygen saturation levels using portable near-infrared spectroscopy in clinically healthy dogs.
        J Vet Emerg Crit Care. 2008; 18: 594-600
        • Hyttel-Sorensen S.
        • Hessel T.W.
        • Greisen G.
        Peripheral tissue oximetry: comparing three commercial near-infrared spectroscopy oximeters on the forearm.
        J Clin Monit Comput. 2013; 28: 149-155
        • Johnston G.M.
        • Eastment J.K.
        • Wood J.
        • Taylor P.M.
        The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.
        Vet Anaesth Analg. 2002; 29: 159-170
        • Johnston G.M.
        • Eastment J.K.
        • Taylor P.M.
        • Wood J.L.
        Is isoflurane safer than halothane in equine anaesthesia? Results from a prospective multicentre randomised controlled trial.
        Equine Vet J. 2004; 36: 64-71
        • Koo T.K.
        • Li M.Y.
        A guideline of selecting and reporting intraclass correlation coefficients for reliability research.
        J Chiropr Med. 2016; 15: 155-163
        • Lima A.
        • Bakker J.
        Noninvasive monitoring of peripheral perfusion.
        Intensive Care Med. 2005; 31: 1316-1326
        • Lima A.
        • Bakker J.
        Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients.
        Rev Bras Ter Intensiva. 2011; 23: 341-351
        • Lima A.
        • van Bommel J.
        • Sikorska K.
        • et al.
        The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients.
        Crit Care Med. 2011; 39: 1649-1654
        • MacLeod D.
        • Ikeda K.
        NONIN Equanox 8004CA advance cerebral oximeter sensor provides valid assessment of true tissue oxygen saturation.
        DUKE University Medical Center, NC, USA2009
        • Masip J.
        • Mesquida J.
        • Luengo C.
        • et al.
        Near-infrared spectroscopy StO2 monitoring to assess the therapeutic effect of drotrecogin alfa (activated) on microcirculation in patients with severe sepsis or septic shock.
        Ann Intensive Care. 2013; 3: 30
        • McKinley B.A.
        • Marvin R.G.
        • Cocanour C.S.
        • Moore F.A.
        Tissue hemoglobin O2 saturation during resuscitation of traumatic shock monitored using near infrared spectrometry.
        J Trauma. 2000; 48: 637-642
        • Myers D.E.
        • Anderson L.D.
        • Seifert R.P.
        • et al.
        Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy.
        J Biomed Opt. 2005; 10: 34017
        • Nicks B.A.
        • Campons K.M.
        • Bozeman W.P.
        Association of low non-invasive near-infrared spectroscopic measurements during initial trauma resuscitation with future development of multiple organ dysfunction.
        World J Emerg Med. 2015; 6: 105-110
        • Pavlisko N.D.
        • Henao-Guerrero N.
        • Killos M.B.
        • et al.
        Evaluation of tissue oxygen saturation with near-infrared spectroscopy during experimental acute hemorrhagic shock and resuscitation in dogs.
        Am J Vet Res. 2014; 75: 48-53
        • Pavlisko N.D.
        • Killos M.
        • Henao-Guerrero N.
        • et al.
        Evaluation of tissue hemoglobin saturation (StO2) using near-infrared spectroscopy during hypoxemia and hyperoxemia in Beagle dogs.
        Vet Anaesth Analg. 2015; 43: 18-26
        • Poeze M.
        Tissue-oxygenation assessment using near-infrared spectroscopy during severe sepsis: confounding effects of tissue edema on StO2 values.
        Intensive Care Med. 2006; 32: 788-789
        • Putnam B.
        • Bricker S.
        • Fedorka
        • et al.
        The correlation of near-infrared spectroscopy with changes in oxygen delivery in a controlled model of altered perfusion.
        Am Surg. 2007; 73: 1017-1022
        • Redford D.
        • Paidy S.
        • Kashif F.
        Absolute and trend accuracy of a new regional oximeter in healthy volunteers during controlled hypoxia.
        Anesth Analg. 2014; 119: 1315-1319
        • Salcedo M.C.
        • Tart K.
        • Hall K.
        A systematic review of human and veterinary applications of noninvasive tissue oxygen monitoring.
        J Vet Emerg Crit Care. 2016; 26: 1-10
        • Shuler M.S.
        • Reisman W.M.
        • Whitesides Jr, T.E.
        • et al.
        Near-infrared spectroscopy in lower extremity trauma.
        J Bone Joint Surg Am. 2009; 91: 1360-1368
        • Soller B.R.
        • Yang Y.
        • Soyemi O.O.
        • et al.
        Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans.
        J Appl Physiol. 2008; 104: 475-481
        • Soller B.R.
        • Sliwa J.
        • Yang Y.
        • et al.
        Simultaneous spectroscopic determination of forearm muscle pH and oxygen saturation during simulated haemorrhage.
        J Near Infrared Spectrosc. 2012; 20: 141-150
        • Sprick J.D.
        • Soller B.R.
        • Rickards C.A.
        The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia.
        Exp Biol Med. 2016; 241: 2007-2013
        • Ward K.R.
        • Ivatury R.R.
        • Barbee R.W.
        • et al.
        Near infrared spectroscopy for evaluation of the trauma patient: a technology review.
        Resuscitation. 2006; 68: 27-44