Abstract
Objective
Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular
effects of two adenosine constant rate infusion (CRI) doses in dogs.
Study design
Experimental, longitudinal repeated measure design.
Animals
Ten healthy purpose-bred Beagle dogs.
Methods
Each dog was sedated with butorphanol. Anaesthesia was induced with propofol intravenously
and maintained with sevoflurane (inspired oxygen fraction = 47–55%). Controlled mechanical
ventilation was used to maintain normocapnia. Two doses of adenosine were administered
as CRIs to each dog: 140 μg kg–1 minute–1 (A140) followed by 280 μg kg–1 minute–1 (A280). Pulse rate, invasive arterial pressure and stroke volume (by magnetic resonance
phase contrast angiography) were measured at baseline, 3 minutes after starting adenosine
and 3 and 10 minutes after discontinuing adenosine. Cardiac output, cardiac index
and approximated systemic vascular resistances (approximate SVR) were calculated.
Additionally, arterial blood gases, co-oximetry, electrolytes, glucose and lactate
were measured and oxygen content and delivery calculated. One-way repeated measures
analysis of variance (p < 0.05) was used for data analysis.
Results
A140 and A280 resulted in a significant decrease in arterial blood pressure [systolic
(p = 0.008), mean (p = 0.003), and diastolic arterial pressure (p = 0.004)] and approximate SVR (p = 0.008) compared with baseline. No significant changes were detected for the other
variables. All values returned to baseline within 3 minutes after adenosine discontinuation.
Conclusions and clinical relevance
Adenosine CRI decreases arterial pressure by vasodilatation in healthy dogs. No additional
effects were observed with the higher dose. The effects in compromised dogs remain
to be investigated.
Keywords
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Article info
Publication history
Published online: February 08, 2019
Accepted:
December 21,
2018
Received:
April 27,
2018
Identification
Copyright
© 2019 Published by Elsevier Ltd on behalf of Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia.
