Abstract
Objective
To compare the clinical effects and sedation scores following either intranasal (IN)
or intramuscular (IM) administration of dexmedetomidine in dogs.
Study design
Prospective, blinded, randomized, clinical study.
Animals
A total of 20 client-owned dogs scheduled for noninvasive diagnostic procedures.
Methods
Dogs were allocated to be administered dexmedetomidine 0.02 mg kg−1 IN (IN group) or IM (IM group). Sedation was scored before and at 5 minute intervals
(for 45 minutes) after drug administration using a composite simple descriptive sedation
scale giving a score of 0 (not sedated) to 13 (well sedated). Respiratory frequency
(fR), heart rate, haemoglobin oxygen saturation (SpO2) and noninvasive arterial blood pressure were recorded every 5 minutes for 45 minutes.
Normally distributed data were analyzed using two-way ANOVA and post hoc Sidak's multiple comparison test. Non-normally distributed data were compared using
the Scheier Ray Hare test and post hoc Mann–Whitney U test. Statistical significance was set at p<0.05.
Results
Weight, age and sex were not different between groups. Dexmedetomidine onset of action
after IN administration was not shorter compared to IM administration (6.3±3.3 versus 9.4±4.6 minutes, p=0.120). Sedation score in the IN group was higher [10 (0–11)] compared to the IM group
[6 (0–8)] (p<0.001). At time of peak sedation, heart rate decreased 56% from baseline values in
the IM group, and 18% in the IN group. No significant differences in SpO2 and fR were found between the two groups at any time point. No undesirable effects were
observed.
Conclusions and clinical relevance
Intranasal dexmedetomidine 0.02 mg kg−1 produced effective sedation with less bradycardia and more profound sedation compared
to IM administration in healthy dogs and may be considered as an alternative route
for dexmedetomidine administration in dogs.
Keywords
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Article info
Publication history
Published online: June 16, 2017
Accepted:
August 24,
2016
Received:
January 12,
2016
Identification
Copyright
© 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
