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Skin lesions following pregabalin administration in a cat

Published:January 10, 2017DOI:https://doi.org/10.1016/j.vaa.2016.03.008
      Pregabalin is an antiepileptic drug that is analogous to gamma-aminobutyric acid and exhibits a structure similar to gabapentin. It has analgesic, anticonvulsant, anxiolytic and sleep-modulating properties in people (
      • Tassone D.M.
      • Boyce E.
      • Guyer J.
      • Nuzum D.
      Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders.
      ). Pregabalin binds to the α2–δ subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, nor-adrenaline, serotonin, dopamine and substance P; it has been shown to be effective in neuropathic pain and is administered for the treatment of fibromyalgia, anxiety and as a sleep-modulating drug (
      • Gairai N.M.
      Pregabalin: its pharmacology and use in pain management.
      ).
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