Pregabalin is an antiepileptic drug that is analogous to gamma-aminobutyric acid and
exhibits a structure similar to gabapentin. It has analgesic, anticonvulsant, anxiolytic
and sleep-modulating properties in people (
Tassone et al., 2007
). Pregabalin binds to the α2–δ subunit of calcium channels, resulting in a reduction
in the release of several neurotransmitters, including glutamate, nor-adrenaline,
serotonin, dopamine and substance P; it has been shown to be effective in neuropathic
pain and is administered for the treatment of fibromyalgia, anxiety and as a sleep-modulating
drug (
Gairai, 2007
).To read this article in full you will need to make a payment
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References
- Center for drug evaluation and research approval package for application number: 21–446.2004 (Last accessed 27 June 2016)
- Pregabalin: its pharmacology and use in pain management.Anesth Analg. 2007; 105: 1805-1815
- Challenge-based pregabalin induced urticaria and angioedema. A case report.Allergol Immunopathol. 2012; 40: 26-48
- Rash associated with pregabalin use.Ann Pharmacother. 2008; 42: 1899-1902
- Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders.Clin Ther. 2007; 29: 26-48
Article Info
Publication History
Published online: January 10, 2017
Accepted:
March 10,
2016
Received:
February 14,
2016
Identification
Copyright
© 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
