Use of rocuronium administered by continuous infusion in dogs



      A clinical trial to determine whether continuous infusion administration technique was suitable for maintaining neuromuscular blockade with rocuronium bromide in dogs.


      Twenty-two dogs, 10 males and 12 females, median age 2 years 4 months, median weight 32 kg undergoing elective surgical procedures under general anaesthesia: ASA classification I or II.

      Materials and methods

      After induction of anaesthesia, neuromuscular function was evaluated using train-of-four (TOF) stimulation of the dorsal buccal branch of the facial nerve. A bolus dose of 0.5 mg kg−1 rocuronium was administered intravenously and an infusion of 0.2 mg kg−1 hour−1 was started immediately. Neuromuscular blockade was assessed visually by counting the number of twitches observed during TOF stimulation repeated at 10-second intervals.


      The bolus dose of rocuronium abolished the response to TOF stimulation in 21 of the 22 dogs. The median onset time of neuromuscular blockade (complete loss of all four twitches) was 82 seconds (range 38–184 seconds). Median infusion duration was 76 minutes (range 20.3–146 minutes).

      Conclusions and clinical relevance

      This protocol of rocuronium administration was considered to be effective in dogs. Constant infusion of rocuronium is easily applicable to clinical practice and further work is required on infusion titration.


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        • Agoston S
        Interactions of volatile anaesthetics with rocuronium bromide in perspective.
        Eur J Anaesthesiol Suppl. 1994; 9: 107-111
        • Ali HH
        • Utting JE
        • Gray C
        Stimulus frequency in the detection of neuromuscular block in humans.
        Br J Anaesth. 1970; 42: 967-978
      1. Auer U (2002) Das musckelrelaxans rocuroniumbromidals dauertropfinfusion in der kombinationsanasthesie beim hund und dessen antagonisierung mit neostigmin und atropine eine klinische studie [The neuromuscular blocking agent rocuronium bromide as continous rate infusion in anaesthetized dogs and the antagonism with neostigmin and atropine, a clinical study]. PhD thesis, University of Vienna, Austria.

      2. Auer U (2003) The effect of low dose rocuronium bromide on eyeball position, muscle relaxation and ventilation in dogs. Proceedings of the Association of Veterinary Anaesthetists Autumn Meeting, Crete, 26–28 September (abstract).

        • Cullen LK
        • Jones RS
        Recording of train-of-four evoked muscle responses from the nose and foreleg in the intact dog.
        Res Vet Sci. 1980; 29: 277-280
        • Donati F
        Cumulation and flexibility with infusions of neuromuscular blocking drugs.
        Can J Anaesth. 2000; 47: 936-942
        • Dugdale AHA
        • Adams WA
        • Jones RS
        The clinical use of the neuromuscular blocking agent rocuronium in dogs.
        Vet Anaesth Analg. 2002; 29: 49-53
        • Ezzine S
        • Varin F
        Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values.
        Br J Anaesth. 2005; 94: 49-56
        • Gijsenbergh F
        • Ramael S
        • Houwing N
        • et al.
        First human exposure of Org 25969 a novel agent to reverse the action of rocuronium bromide.
        Anesthesiology. 2005; 103: 695-703
        • Harrison MJ
        Prediction of infusion rates of rocuronium using the bolus test dose technique.
        Anaesthesia. 1997; 52: 37-40
        • Jellish WS
        • Brody M
        • Sawicki K
        • et al.
        Recovery from neuromuscular blockade after either bolus and prolonged infusions of cisatracurium or rocuronium using either isoflurane or propofol-based anesthetics.
        Anesth Analg. 2000; 91: 1250-1255
        • Jones RS
        • Brearley JC
        Atracurium infusion in the dog.
        J Small Anim Pract. 1987; 28: 197-201
        • Jones RS
        • Young LE
        Vecuronium infusion in the dog.
        J Small Anim Pract. 1991; 32: 509-512
        • Martineau RJ
        • St-Jean B
        • Kitts JB
        • et al.
        Cumulation and reversal with prolonged infusions of atracurium and vecuronium.
        Can J Anaesth. 1992; 39: 670-676
        • McCoy EP
        • Mirakhur RK
        • Maddineni VR
        • et al.
        Pharmacokinetics of rocuronium after bolus and continuous infusion during halothane anaesthesia.
        Br J Anaesth. 1996; 76: 29-33
        • Miller DR
        • Wherrett C
        • Hull K
        • et al.
        Cumulation characteristics of cisatracurium and rocuronium during continuous infusion.
        Can J Anaesth. 2000; 47: 943-949
        • Neal SMcD
        • Manthri PR
        • Gadiyar V
        • et al.
        Histaminoid reactions associated with rocuronium.
        Br J Anaesth. 2000; 84: 108-111
        • Oris B
        • Crul JF
        • Vandermeersch E
        • et al.
        Muscle paralysis by rocuronium during halothane, enflurane, isoflurane, and total intravenous anesthesia.
        Anesth Analg. 1993; 77: 570-573
        • Rose M
        • Fisher M
        Rocuronium: high risk for anaphylaxis.
        Br J Anaesth. 2001; 86: 678-682
        • Saldien V
        • Vermeyen M
        • Wuyts FL
        Target-controlled infusion of rocuronium in infants, children and adults: A comparison of the pharmacokinetic and pharmacodynamic relationship.
        Anesth Analg. 2003; 97: 44-49
        • Sparr HJ
        • Wierda JM
        • Proost JH
        • et al.
        Pharmacodynamics and pharmacokinetics of rocuronium in intensive care patients.
        Br J Anaesth. 1997; 78: 267-273
        • Vermeyen KM
        • Hoffmann VL
        • Saldien V
        Target controlled infusion of rocuronium: analysis of effect data to select a pharmacokinetic model.
        Br J Anaesth. 2003; 90: 183-188
        • Woloszczuk-Gebicka B
        • Lapczynski T
        • Wierzejski W
        The influence of halothane, isoflurane and sevoflurane on rocuronium infusion in children.
        Acta Anaesthesiol Scand. 2001; 45: 73-77