Abstract
Objective
A clinical trial to determine whether continuous infusion administration technique
was suitable for maintaining neuromuscular blockade with rocuronium bromide in dogs.
Animals
Twenty-two dogs, 10 males and 12 females, median age 2 years 4 months, median weight
32 kg undergoing elective surgical procedures under general anaesthesia: ASA classification
I or II.
Materials and methods
After induction of anaesthesia, neuromuscular function was evaluated using train-of-four
(TOF) stimulation of the dorsal buccal branch of the facial nerve. A bolus dose of
0.5 mg kg−1 rocuronium was administered intravenously and an infusion of 0.2 mg kg−1 hour−1 was started immediately. Neuromuscular blockade was assessed visually by counting
the number of twitches observed during TOF stimulation repeated at 10-second intervals.
Results
The bolus dose of rocuronium abolished the response to TOF stimulation in 21 of the
22 dogs. The median onset time of neuromuscular blockade (complete loss of all four
twitches) was 82 seconds (range 38–184 seconds). Median infusion duration was 76 minutes
(range 20.3–146 minutes).
Conclusions and clinical relevance
This protocol of rocuronium administration was considered to be effective in dogs.
Constant infusion of rocuronium is easily applicable to clinical practice and further
work is required on infusion titration.
Keywords
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Article info
Publication history
Accepted:
June 23,
2006
Received:
December 14,
2005
Identification
Copyright
© 2007 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Inc. All rights reserved.
