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Comparative study of epidural xylazine or clonidine in horses

      Abstract

      Objective

      To evaluate the cardiorespiratory and behavioural effects of epidural xylazine (XYL) or clonidine (CLO) in horses.

      Study design

      Blinded, randomized experimental study.

      Animals

      Twelve healthy Arabian yearling horses weighing 117–204 kg were randomly allocated into two groups: XYL (n = 6) and CLO (n = 6).

      Methods

      An epidural catheter was inserted and a facial arterial catheter was placed and the next day the horses were restrained in stocks. Baseline values for heart (HR) and respiratory (RR) rates, arterial pressure and behavioural responses were evaluated before (T0) and 10, 20, 30, 45, 60, 90 and 120 minutes after epidural injection (T10–T120). The horses received 0.2 mg kg−1 of XYL or 5 μg kg−1 CLO; adjusted to (3.4 + (body weight in kg × 0.013) mL with saline. Data were analysed by the Kolmogorov–Smirnov test, one-way anova with repeated measures, and one-way anova followed by a Student–Newman–Keuls test or Fisher's exact test, as necessary. Significance was set at p ≤ 0.05.

      Results

      Sedation and ataxia were seen at T10, persisting until T120 in four and three horses, respectively, in XYL and all horses in CLO respectively. Two XYL and one CLO horses became recumbent at T45 and T25 respectively. Penile prolapse occurred in four of five males at T30 and T45, in the XYL and CLO groups, respectively, resolving by T120. Tail relaxation was present from T10 to T120 in all horses in XYL and in four horses in CLO. Head drop was observed from T20 to T60 and from T10 to T120 in XYL and CLO respectively. Respiratory rate decreased significantly only at T45 in the CLO group. Heart rate and arterial blood pressure remained stable.

      Conclusions and clinical relevance

      Epidural CLO and XYL produce similar cardiorespiratory and behavioural changes but neither would be safe to use clinically at the doses used in this study.

      Keywords

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      References

        • Bernard JM
        • Kick O
        • Bonnet F
        Which way for the administration of alpha-2 adrenergic agents to obtain the best analgesia?.
        Cah Anesthesiol. 1994; 42: 223-228
        • Bouaziz H
        • Hewitt C
        • Eisenach JC
        Subarachnoid neostigmine potentiation of alpha-2-adrenergic agonist analgesia. Dexmedetomidine versus clonidine.
        Reg Anesth. 1995; 20: 121-127
        • Campagnol D
        • Monteiro ER
        • Luna SPL
        • et al.
        Cardiac, respiratory and analgesic effects of clonidine and tramadol associated with lidocaine epidural anesthesia in dogs.
        Rev Bras Cienc Vet. 2002; 9: 286-288
        • Castro MI
        • Eisenach JC
        Pharmacokinetics and dynamics of intravenous, intrathecal, and epidural clonidine in sheep.
        Anesthesiology. 1989; 71: 418-425
        • Chevalier HM
        • Provost PJ
        • Karas AZ
        Effect of caudal epidural xylazine on intraoperative distress and post-operative pain in Holstein heifers.
        Vet Anaesth Analg. 2004; 31: 1-10
        • Coombs DW
        • Fratkin JD
        Neurotoxicity of spinal agents.
        Anesthesiology. 1987; 66 (editorial).: 724-725
        • De Rossi R
        • Segura IAG
        Analgesic, haemodynamic and respiratory effects of caudal epidural xylazine in equines.
        Hora Vet. 2001; 120: 49-53
        • De Rossi R
        • Bucker GV
        • Varela JV
        Perineal analgesic actions of epidural clonidine in cattle.
        Vet Anaesth Analg. 2003; 30: 64-71
        • Eisenach JC
        • Grice SC
        Epidural clonidine does not decrease blood pressure or spinal cord blood flow in awake sheep.
        Anesthesiology. 1988; 68: 335-340
        • Eisenach JC
        • Dewan DM
        • Rose JC
        • et al.
        Epidural clonidine produces antinociception, but not hypotension, in sheep.
        Anesthesiology. 1987; 66: 496-501
        • Eisenach JC
        • Lysak SZ
        • Viscomi CM
        Epidural clonidine analgesia following surgery: phase I.
        Anesthesiology. 1989; 71: 640-646
        • Eisenach JC
        • Detweiler D
        • Hood D
        Hemodynamic and analgesic actions of epidurally administered clonidine.
        Anesthesiology. 1993; 78: 277-287
        • Eisenach JC
        • De Kock R
        • Klimscha W
        Alpha2-adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984–1995).
        Anesthesiology. 1996; 83: 655-674
        • England GC
        • Clarke KW
        Alpha 2 adrenoceptor agonists in the horse – a review.
        Br Vet J. 1996; 152: 641-657
        • England GCW
        • Clarke KW
        • Goossens L
        A comparison of the sedative effects of three alpha-2 adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse.
        J Vet Pharmacol Ther. 1992; 15: 194-201
        • Fikes LW
        • Lin HC
        • Thurmon JC
        A preliminary comparison of lidocaine and xylazine as epidural analgesics in ponies.
        Vet Surg. 1989; 18: 85-86
        • Ghignone M
        • Calvillo O
        • Quintin L
        • et al.
        Haemodynamic effects of clonidine inject epidurally in halothane-anaesthetized dogs.
        Can J Anaesth. 1987; 34: 46-50
        • Glynn CJ
        • Teddy PJ
        • Jamous MA
        • et al.
        Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury.
        Lancet. 1986; 2: 1249-1250
        • Glynn C
        • Dawson D
        • Sanders R
        A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain.
        Pain. 1988; 34: 123-128
        • Goodrich LR
        • Nixon AJ
        How to alleviate acute and chronic hindlimb pain in horses. 49th Annual Convention of the American Association of Equine Practitioners 2003 New Orleans, Louisiana.
        ([accessed on 27 September 2006].)
        • Gordh TE
        • Ekman E
        • Lagerstedt AS
        Evaluation of possible spinal neurotoxicity of clonidine.
        Ups J Med Sci. 1984; 89: 266-273
        • Gordh Jr, T
        • Feuk U
        • Norlén K
        Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs.
        Anesth Analg. 1986; 65: 1312-1318
        • Gordh TE
        • Post C
        • Oisson Y
        Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration.
        Anesth Analg. 1986; 65: 1303-1311
        • Grubb TL
        • Riebold TW
        • Hubber MJ
        Comparison of lidocaine, xylazine, and xylazine/lidocaine for caudal epidural analgesia in horses.
        J Am Vet Med Assoc. 1992; 201: 1187-1190
        • Hodgson PS
        • Neal JM
        • Pollock JE
        • et al.
        The neurotoxicity of drugs given intrathecally (spinal).
        Anesth Analg. 1999; 88: 797-809
        • Jöchle WS
        • Hamm D
        Sedation and analgesia with Domosedan (detomidine hydrochloride) in horses: dose response studies on efficacy and its duration.
        Acta Vet Scand Suppl. 1986; 82: 69-84
        • Kalia PK
        • Madan R
        • Batra RK
        • et al.
        Clinical study on epidural clonidine for postoperative analgesia.
        Indian J Med Res. 1986; 83: 550-552
        • Kamerling SG
        • Cravens WMT
        • Bagwell CA
        Objective assessment of detomidine induced analgesia and sedation in the horse.
        Eur J Pharmacol. 1988; 151: 1-8
        • LeBlanc PH
        • Caron JP
        Clinical use of epidural xylazine in the horse.
        Equine Vet J. 1990; 22: 180-181
        • LeBlanc PH
        • Eberhart SW
        Cardiopulmonary effects of epidurally administered xylazine in the horse.
        Equine Vet J. 1990; 22: 389-391
        • LeBlanc PH
        • Caron JP
        • Patterson JS
        • et al.
        Epidural injection of xylazine for perineal analgesia in horses.
        J Am Vet Med Assoc. 1988; 193: 1405-1408
        • Natalini CC
        Epidural anesthesia and analgesia in equines.
        in: Proceedings of the 4th Brazilian Congress of Veterinary Surgery and Anesthesiology. 2000 (Goiânia, Brazil (CD-ROM).)
        • Olivero VYI
        • Munoz CJH
        • Sánchez VJ
        • et al.
        Utility of the clonidine for via peridural in anesthesiology.
        Rev Med Hosp Gen Mex. 2000; 63: 261-266
        • Pernow B
        Substance P.
        Pharmacol Ver. 1983; 35: 85-141
        • Raffe MR
        • Tranquilli WJ
        Classifying commonly used analgesic agents. Symposium of pain management.
        Vet Med. 1989; 84: 687-690
        • Schwinn DA
        • Corrja-Sales C
        • Page SO
        • et al.
        Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: in vivo and in vitro studies.
        J Pharmacol Exp Ther. 1991; 259: 1147-1151
        • Segura IG
        • Rossi R
        • Santos M
        • et al.
        Epidural injection of ketamine for perineal analgesia in the horse.
        Vet Surg. 1998; 27: 384-391
        • Skarda RT
        The physiologic responses after caudal epidural administration of xylazine in cattle and detomidine in horses.
        in: Proceedings of the Symposium on Animal Pain and its Control, New York. 1990: 292-302
        • Skarda RT
        Local and regional anaesthesia and analgesia techniques: horses.
        in: Thurmon JC Tranquilli NJ Benson GJ Lumb & Jones' Veterinary Anesthesia. 3rd edn. Lippincott Williams & Wilkins, Baltimore, MD1996: 448-478
        • Skarda RT
        • Muir 3rd, WW
        Analgesic, hemodynamic, and respiratory effects of caudal epidurally administered xylazine hydrochloride solution in mares.
        Am J Vet Res. 1996; 57: 193-200
        • Skarda RT
        • Muir WW
        Comparison of antinociceptive, cardiovascular, and respiratory effects, head ptosis, and position of pelvic limbs in mares after caudal epidural administration of xylazine and detomidine hydrochloride solution.
        Am J Vet Res. 1996; 57: 1338-1345
        • Smith BD
        • Baudendistel LJ
        • Gibbons JJ
        • et al.
        A comparison of two epidural alpha 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats.
        Anesth Analg. 1992; 74: 712-718
        • Spinosa HS
        • Górniak SL
        • Bernadi MM
        Farmacologia Aplicada à Medicina Veterinária. Guanabara Koogan, Rio de Janeiro, Brazil1996
        • Timmermans PB
        • De Jonge A
        • Van Zwieten PA
        Comparative quantitative studies on central and peripheral alpha-adrenoceptors.
        Chest. 1983; 83: 354-357
        • Valadão CAA
        • Pinto MRA
        • Marques JA
        • et al.
        Epidural analgesia with xylazine. Surgical and hemogasimetric evaluation.
        Ars Vet. 1990; 6: 125-135
        • Wintzer HJ
        • Krause D
        • Siedentopf C
        • et al.
        Clonidine as a sedative in horses.
        Berl Munch Tierarztl Wochenschr. 1985; 98: 190-193
        • Yaksh TL
        Effects of spinally administered agents on spinal cord flow. A need for further studies.
        Anesthesiology. 1983; 59: 173-175
        • Yaksh TL
        • Reddy SVR
        Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists, and baclofen.
        Anesthesiology. 1981; 54: 451-467