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Atipamezole changes the antinociceptive effects of butorphanol after medetomidine–ketamine anaesthesia in rats

      Abstract

      Objective

      To investigate the effects of atipamezole administered before butorphanol, on tail-flick latency (TFL) and also following medetomidine–ketamine anaesthesia in rats.

      Study design

      Prospective, randomized experimental study.

      Animals

      Thirty-four adult male Sprague–Dawley rats weighing 260–390 g.

      Methods

      TFL in 50 °C water was used to measure antinociception. In the first experiment, rats received saline (n = 5) or atipamezole (n = 5) followed by butorphanol treatments. In the second experiment, three groups of rats received saline (n = 8), atipamezole (n = 8) or atimpamezole (n = 8) followed by butorphanol 60 minutes after medetomidine–ketamine administration.

      Results

      In the first experiment, butorphanol significantly increased TFL compared to baseline. Atipamezole significantly decreased this effect. In the second experiment, TFL was significantly increased after recovery from medetomidine–ketamine anaesthesia compared to baseline. This was almost completely blocked by atipamezole. Atipamezole with butorphanol after recovery from the anaesthesia significantly reduced TFL compared to saline but still significantly increased TFL compared to the baseline.

      Conclusion and clinical relevance

      Atipamezole attenuated the analgesic effects of butorphanol. When postoperative atipamezole is used to hasten recovery from anaesthesia in rats, it may interfere with the postoperative analgesic effect of butorphanol.

      Keywords

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