Advertisement

Amantadine, an N-Methyl-D-Aspartate antagonist, for treatment of chronic neuropathic pain in a dog

      Neuropathic pain is increasingly becoming recognised in veterinary patients. Implicated in a multitude of conditions, it should be considered in patients with chronic and misleading symptoms of pain. Reports of neuropathic pain in dogs describe allodynia, hyperalgesia, dysaesthesia and paroxysmal pain episodes as prominent clinical features in each case (Cashmore et al.
      • Cashmore R
      • Harcourt-Brown T
      • Freeman P
      • et al.
      Clinical diagnosis and treatment of suspected neuropathic pain in three dogs.
      ). This stresses the importance of behavioural indicators in assisting diagnosis.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Veterinary Anaesthesia and Analgesia
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Brown DC
        • Boston RC
        • Coyne JC
        • et al.
        Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis.
        J Am Vet Med Assoc. 2008; 233: 1278-1283
        • Cashmore R
        • Harcourt-Brown T
        • Freeman P
        • et al.
        Clinical diagnosis and treatment of suspected neuropathic pain in three dogs.
        Aust Vet J. 2009; 87: 45-50
        • Lascelles BDX
        • Gaynor JS
        • Smith ES
        • et al.
        Amantadine in a Multimodal Analgesic Regimen for Alleviation of Refractory Osteoarthritis Pain in Dogs.
        J Vet Intern Med. 2008; 22: 53-59
        • Meintjes RA
        An overview of the physiology of pain for the veterinarian.
        Vet J. 2012; 193: 344-348
        • Wiseman ML
        • Nolan AM
        • Reid J
        Preliminary study on owner-reported behaviour changes associated with chronic pain in dogs.
        Vet Rec. 2001; 149: 423-424