Abstract
Objective
To compare the respective effects of propofol and emulsified isoflurane administered
alone and in combination with dexmedetomidine on the quality of induction of anesthesia,
physiological variables and recovery in dogs.
Study design
Prospective, randomized, experimental trial.
Animals
Thirty-six adult mixed-breed dogs.
Methods
Animals were randomly assigned to one of four induction protocols: propofol alone
(group P); emulsified isoflurane alone (group EI); both propofol and dexmedetomidine
(group PD), or both emulsified isoflurane and dexmedetomidine (group EID). Pulse rate
(PR), respiratory rate (fR), non-invasive arterial blood pressure and arterial blood gases were measured at
baseline, before induction, immediately after intubation (time 0), and at 5 minute
intervals until the dog began to swallow and the trachea was extubated. The quality
of induction and recovery, and degree of ataxia were scored by a single investigator
unaware of group assignment. The durations of anesthesia and recovery, and the incidence
of adverse events were recorded.
Results
There were no clinically significant differences among the groups in induction quality.
Systolic arterial pressure was lower in EID compared with P at 5 minutes. PR and fR were lower in PD and EID compared with P after induction. The PaCO2 at 5 minutes was higher than at baseline in group P. Ataxia score was lower in EID
than in P. Time from induction to extubation and time from extubation to sternal recumbency
were lower in EID compared with PD.
Conclusions and clinical relevance
There were no clinically significant differences among the groups in induction quality.
In PD and EID, but not in P, PR and fR were decreased after induction. The EID combination resulted in smooth and rapid
induction and recovery and thus may be useful clinically for induction of anesthesia.
Keywords
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Article info
Publication history
Accepted:
March 19,
2015
Received:
November 10,
2014
Identification
Copyright
© 2016 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Inc. All rights reserved.
