Abstract
Objective
To determine the effects of morphine, methadone, hydromorphone or oxymorphone on the
thermal threshold in cats, following buccal and intravenous (IV) administration.
Study design
Randomized crossover study.
Animals
Six healthy adult female ovariohysterectomized cats weighing 4.5 ± 0.4 kg.
Methods
Morphine sulfate (0.2 mg kg−1 IV or 0.5 mg kg−1 buccal), methadone hydrochloride (0.3 mg kg−1 IV or 0.75 mg kg−1 buccal), hydromorphone hydrochloride (0.1 mg kg−1 IV or 0.25 mg kg−1 buccal) or oxymorphone hydrochloride (0.1 mg kg−1 IV or 0.25 mg kg−1 buccal) were administered. All cats were administered all treatments. Skin temperature
and thermal threshold were measured in duplicate prior to drug administration, and
at various times up to 8 hours after drug administration. The difference between thermal
threshold and skin temperature (ΔT) was analyzed.
Results
Administration of methadone and hydromorphone IV resulted in significant increases
in ΔT at 40 minutes after drug administration. Buccal administration of methadone
resulted in significant increases in thermal threshold, although no significant difference
from baseline measurement was detected at any time point. IV administration of morphine
and oxymorphone, and buccal administration of morphine, hydromorphone and oxymorphone
did not cause significant thermal antinociception.
Conclusion and clinical relevance
At the doses used in this study, IV administration of methadone and hydromorphone,
and buccal administration of methadone resulted in transient thermal antinociception.
The results of this study do not allow us to predict the usefulness of these drugs
for providing analgesia in clinical patients.
Keywords
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Article info
Publication history
Accepted:
December 5,
2015
Received:
July 27,
2015
Identification
Copyright
© 2016 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Inc. All rights reserved.
